The PNP Technology
Unique Properties of the E. coli PNP System
- Targets all solid tumors
- E. coli PNP selectively activates a well characterized, FDA-approved anti-tumor agent, fludarabine phosphate
- Effectiveness proven in multiple mouse models of human cancers (ovarian, lymphoma, colon, brain, liver, prostate, pancreatic, others)
- Safety/pharmacology demonstrated in numerous preclinical studies
- Both the drug delivery vehicle and the chemotherapeutic component have previously been evaluated in human subjects and are known to be safe and well tolerated
- Replaces the use of radiation therapy with a less toxic, less debilitating therapeutic strategy
- Novel mechanism of cell kill resulting from inhibition of RNA and protein synthesis ultimately killing both dividing and non-dividing tumor cells
- Multi-billion dollar market potential